Synthesis of Biscoumarin Derivatives as Biological Compounds Using Cellulose Sulfonic Acid

Cellulose sulfonic acid efficiently catalyzes the one-pot reaction of 4hydroxycoumarin and aryl aldehydes under mild reaction conditions to yield biscoumarin derivatives in high yields. This method is of great value because of its easy processing, short reaction time and high yields. We anticipate the present method will receive the attention of medicinal chemists and be used for elaborate synthesis and pharmaceutical screening of biscoumarin based molecules.